科学研究

Principal Investigators

Minmin Luo Ph.D.

E-mail: luominmin@@cibr.ac.cn; luominmin@@nibs.ac.cn(remove one@ when use it)

Phone: +86 10 8072 3791

Lab Homepage:

Education

B.S. in Psychology, Beijing University,China, 1995

M.S. in Computer Science, University  of Pennsylvania, 1997

Ph.D. in Neuroscience, University of Pennsylvania, 2000

Professional Experience

03/2018 – present         Director and Distinguished Investigator,

                                       Chinese Institute for Brain Research, Beijing(NIBS) ,Beijing, China

01/2013 – present      Investigator,

05/2010 – 12/2012     Associate Investigator,

10/2005 – present         Investigator and Laboratory Head,

10/2005 – 04/2010     Assistant Investigator and Director of Imaging Facility,

                                       National Institute of Biological Science,Beijing(NIBS) ,Beijing, China

03/2009 – present         Professor,

                                       School of Life Sciences, Tsinghua University(Tenured 5/2015), Beijing, China

08/2004 – 09/2005        Investigator and Laboratory Head

                                       Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

12/1999 – 70/2004        Postdoctoral Research (Advisor: Lawrence C. Katz)

                                Howard Hughes Medical Institute and Duke University, NC, USA

01/1997 – 12/1999     Ph.D. Thesis Research (Advisor: David J. Perkel)

                                Department of Neuroscience, University of Pennsylvania, PA, USA

Research Description

        Reward and Punishment are critical to animal survial and reproduction, and Have a great impact on our lives. To elucidate how neural circuit processes reward and punishment signals. I particularly focus on the functions and mechanisms of the brain 5-HT neurons in the dorsal raphe and the neural pathway from the medial habenula to the interpeduncular nucleus. My laboratory uses integrative approaches including electrophysiology, optical imaging and optogenetics, molecular genetics, and behavioral assays, and aims to revealing the role of the associated neural circuit at the molecular, cellular, physiological, and circuit levels. We also take the advantage of whole cell patch clamp and optical imaging to determine the cellular machanism and signal transduction pathways of drugs disturbing reward and punishment related behaviours  which get involved in human mental disorders, such as depression, sczhophrenia, and drug addiction. We expect to understand the basic neural circuits that control reward and punishment related behaviours, and also contribute to clincial treatment.  

Publications

1.Lin R*CA, Liang J*, Wang R, Yan T, Zhou Y, Liu Y, Feng Q, Li A, Gong H, Luo MCA (2020) The raphe dopamine system controls the expression of incentive memory. Neuron doi 10.1016/j.neuron.2020.02.009.

2.Lu L*, Wang R, Luo MCA (2020) An optical brain-to-brain interface supports rapid information transmission for precise locomotion control. Science China Life Sciences doi 10.10.0.7/s11427-020-1675-x. 

3.Lu L*, Ren Y*, Yu T, Liu Z, Wang S, Tan L, Zeng J, Feng Q, Lin R, Liu Y, Guo Q, Luo MCA (2020) Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus. Nature Communications doi 10.1038/s41467-019-14116-y.

4.Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, Tao Q, Xiao J, Yuan T, An K, Zhao H, Pu M, Xu F, Xue T, Luo M, So KFCA, Ren CCA (2019) A visual circuit related to habenula underlies the antidepressive effects of light therapy. Neuron 102, 128-142. e8

5.Sun Q, Li X, Ren M, Zhao M, Zhong Q, Ren Y, Luo P, Ni H, Zhang X, Zhang C, Yuan J, Li A, Luo M, Gong H, Luo QCA (2019) A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex. Nature Neurosci doi 10.1038/s41593-019-0429-9.

6.Li Y, Liu Z, Guo Q, Luo M (2019) Long-term Fiber Photometry for Neuroscience Studies Neuroscience Bulletin 35, 425-433.

7.Ren J, Isakova A, Friedmann D, Zeng J, Grutzner S, Pun A, Zhao GQ, Kolluru SS, Wang R, Lin R, Li P, Li A, Raymond JL, Luo Q, Luo M, Quake SR, Luo L (2019) Serotonin Neurons in the Dorsal and Medial Raphe Nuclei: from Single-Cell Transcriptomes to Whole-Brain Projections. Elife; 8: e49424.

8.Zhao Y, Liu C, Liu Z, Luo W, Li L, Cai X, Liang D, Su Y, Ding H, Wang Q, Yin L, Guan J, Luo M, Sheng XCA (2019) Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals. IEEE Transactions on Electron Devices 66(1): 785-792, doi:10.1109/TED.2018.2882397.

9.Lin R*, Wang R*, Yuan J*, Feng Q, Zhou Y, Zeng S, Ren M, Jiang S, Ni H, Zhou C, Gong HCA, Luo MCA (2018) Cell type- and projection-specific brain-wide reconstruction of single neurons. Nature Methods 15: 1033–1036, doi:10.1038/s41592-018-0184-y.

10.Wei C*, Han X*, Weng D, Feng Q, Qi X, Li JCALuo MCA (2018) Response dynamics of midbrain dopamine neurons and serotonin neurons to heroin, nicotine, cocaine, and MDMA. Cell Discovery 4(1): 60, doi:10.1038/s41421-018-0060-z.

11.Jing M, Zhang P, Wang G, Jiang H, Mesik L, Feng J, Zeng J, Wang S, Looby J, Guagliardo NA, Langma LW, Lu J, Zuo Y, Talmage DA, Role LW, Barrett PQ, Zhang LI, Luo M, Song Y, Zhu J, Li YCA (2018) A genetically-encoded fluorescent acetylcholine indicator A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology 36(8): 726-737, doi:10.1038/nbt.4184

12.Ding H, Lu L, Shi Z, Wang D, Li L, Li X, Ren Y, Liu C, Cheng D, Kim H, Giebink NC, Wang X, Yin L, Zhao L, Luo M, Sheng XCA (2018) Microscale optoelectronic infrared-to-visible upconversion devices and their use as injectable light sources. PNAS 115(26): 6632-6637, doi:10.1073/pnas.1802064115. 

13.Cai D, Yue Y, Su X, Liu M, Wang Y, You L, Xie F, Deng F, Chen F, Luo M, Yuan KCA (2018) Distinct Anatomical Connectivity Patterns Differentiate Subdivisions of the Nonlemniscal Auditory Thalamus in Mice. Cerebral Cortex doi: 10.1093/cercor/bhy115.

14.Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi Z, Tang N, Shao F, Luo MCA (2018) A hybridization chain-reaction-based method for amplifying immunosignals. Nature Methods 15(4): 275-278, doi:10.1038/nmeth.4611. 

15.Li Y, Zeng J, Zhang J, Yue C, Zhong W, Liu Z, Feng Q, Luo MCA (2018) Hypothalamic Circuits for Predation and Evasion Neuron 97: 911–924, doi:10.1016/j.neuron.2018.01.005. Featured with Cover and Video Abstract. 

16.Ables JL, Görlich Antolin-Fontes B, Wang C, Lipford S, Riad MH, Ren J, Hu F, Luo M, Kenny PJ, Heintz N, Ibañez-Tallon ICA (2017) A Retrograde inhibition by a specific subset of interpeduncular 5 nicotinic neurons regulates nicotine preference. PNAS 114(49): 13012-13017, doi:10.1073/pnas.1717506114.

17.Qi Z, Guo Q, Liu Q, Chen M, Gong H, Zeng S, Luo Q, Luo M, Fu LCA (2017) GRIN lens based high speed confocal system for deep brain calcium imaging. International Conference on Photonics and Imaging in Biology and Medicine doi:10.1364/PIBM.2017.T1A.4.

18.Zhong W, Li Y, Feng Q, Luo MCA (2017) Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons. J Neurosci 37: 8863-8875. 

19.Luo J., Feng Q, Wei LCA, Luo MCA (2017) Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice. Cell Res 27(7): 950-953, doi:10.1038/cr.2017.52.

20.Zhao Z, Wang L, Gao W, Hu F, Zhang J, Ren Y, Lin R, Feng Q, Cheng, M, Ju D, Chi Q, Wang D, Song S, Luo M, Zhan CCA (2017) A central catecholaminergic circuit controls blood glucose levels during stress Neuron 95(1): 138-152, doi:10.1016/j.neuron.2017.05.031.

21.Wang D, Li Y, Feng Q, Guo Q, Zhou J, Luo MCA (2017) Learning shapes the aversion and reward responses of lateral habenula neurons. eLife 6:e23045.

22.Huang L, Yuan T, Tan M, Xi Y, Hu Y, Tao Q, Zhao Z, Zheng J, Han Y, Xu F, Luo M, Sollars PJ, Pu M, Pickard GE, So K-FCA, Ren CCA (2017) A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behavior Nature Comms 8: 14908, doi:10.1038/ncomms14908. 

23.Ren JCA, Zhang M, Li T, Zhang J, Lin R, Chen S, Luo M, Dong MCA (2016) Quantitative proteomics of sleep-deprived mouse brains reveals global changes in mitochondrial proteins. PLoS ONE 11 doi:10.1371/journal.pone.0163500. 

24.Zhang J, Tan L, Ren Y, Liang J, Lin R, Feng Q, Zhou J, Hu F, Ren J, Wei C, Yu T, Zhuang Y, Bettler B, Wang F, Luo MCA (2016) Presynaptic excitation via GABAB receptors in habenula cholinergic neurons regulates fear memory expression. Cell 166: 716–728, doi:10.1016/j.cell.2016.06.026. 

25.Hu R, Zhang J, Luo M, Hu JCA (2016) Response patterns of GABAergic neurons in the anterior piriform cortex of awake mice. Cerebral Cortex doi:10.1093/cercox/bhw175. 

26.Glajch K, Kelver D, Hegeman D, Cui Q, Xenias H, Augustine E, Hernandez V, Verma N, Huang T, Luo M, Justice N, Chan SCA (2016) Npas1+ pallidal neurons target striatal projection neurons. J Neurosci 36(20): 5472-5488. 

27.Li Y, Zhong W, Wang D, Feng Q, Liu Z, Zhou J, Jia C, Hu F, Zeng J, Guo Q, Fu L, Luo MCA (2016) Serotonin neurons in the dorsal raphe nucleus encode reward signals. Nature Comms 7: 10503, doi:10.1038/ncomms10503.

28.Soria-Gómez E, Busquets-Garcia A, Hu F, Mehidi A, Cannich A, Roux L, Louit I, Alonso L, Wiesner T, Georges F, Verrier D, Vincent P, Ferreira G, Luo M, Marsicano GCA (2015) Habenular CB1 receptors control the expression of aversive memories. Neuron 88: 306-13, doi:10.1016/j.neuron.2015.08.035.

29.Guo Q*, Zhou J*, Feng Q, Lin R, Gong H, Luo Q, Zeng S, Luo MCA, Fu LCA (2015) Multi-channel fiber photometry for population neuronal activity recording. Biomedical Optics Express 6: 3919-3931, doi:10.1364/BOE.6.003919.

30.Guo Q, Wang D, He X, Feng Q, Lin R, Xu F, Fu L, Luo MCA (2015) Whole-brain mapping of inputs to projection neurons and cholinergic interneurons in the dorsal striatum. PLoS ONE doi:10.1371/journal.pone.0123381. 

31.Wang D, He X, Zhao Z, Feng Q, Lin R, Sun Y, Ding T, Xu FCALuo MCA, Zhan CCA  (2015) Whole-brain mapping of the direct inputs and axonal projections of pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons. Front. Neuroanat. doi:10.3389/fnana.2015.00040.

32.Gao L, Jiang Y, Mu L, Liu Y, Wang F, Wang P, Zhang A, Tang N, Chen T, Luo M, Yu L, Gao S, Chen LCA (2015) Efficient Generation of Mice with Consistent Transgene Expression by FEEST. Scientific reports 5: 16284.

33.Zhou J, Jia C, Feng Q, Bao J, Luo MCA (2015) Prospective coding of dorsal raphe reward signals by the orbitofrontal cortex. J Neurosci 35: 2717-2730. 

34.Liu Z*, Zhou J*, Li Y, Hu F, Wang D, Lu Y, Ma M, Feng Q, Zhang J, Zeng J, Bao, Kim J, Chen Z, Mestikawy SE, Luo MCA (2014) Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron 81: 1360–1374. (F1000 recommendation)

35.Han Y, Shi Y-F, Xi W, Zhou R, Tan Z-B, Wang H, Li X-M, Chen Z, Feng G, Luo M, Huang Z-L, Duan SCA, Yu Y-QCA (2014) Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions. Current Biology 24: 693–698.

36.Wang S, Tan Y, Zhang J, Luo MCA (2013) Pharmacogenetic activation of midbrain dopamine neurons induces hyperactivity. Neurosci Bulletin 29: 517-524.

37.Zhan CCA, Zhou J, Feng Q, Zhang J, Lin S, Bao J, Wu P, Luo MCA (2013) Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci 33: 3624 –3632. (F1000 recommendation)

38.Hu F, Ren J, Zhang J, Zhong W, Luo MCA (2012) Atrial natriuretic peptide blocks synaptic transmission by activating Phosphodiesterase 2A and eliminating basal PKA activity in presynaptic terminals. PNAS 109: 17681–17686. (F1000 recommendation)

39.Ma M, Luo MCA (2012) Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb. J Neurosci 32: 10105-10116. (TWIJ feature article). 

40.Gong R*, Ding C*, Hu J*, Lu Y, Liu F, Mann E, Xu F, Cohen MB and Luo MCA (2011) Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333: 1642-1646. 

41.Zhao S, Ting JT, Atallah HE, Qiu L, Tan J, Gloss B, Augustine GJ, Deisseroth K, Luo M,  Graybiel AM, Feng GCA (2011) Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nature Methods 8: 745-752. 

42.Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S, Feng G, Luo MCA (2011) Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron 69: 445-452. (Cover; F1000 recommendation)

43.Zhan C, Luo MCA (2010) Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neurosci 30: 16662–16672. 

44.Han J, Luo MCA (2010) Loss of CO2 sensing by the olfactory system of CNGA3 knockout mice. Curr Zoology 56: 793−799.

45.Gao L, Hu J, Zhong C, Luo MCA (2010) Integration of CO2 and odorant signals in the mouse olfactory bulb. Neuroscience 170: 881–892.

46.Tan J, Savigner A, Ma M, and Luo MCA (2010) Odor information processing by the olfactory bulb analyzed in gene-targeted mice. Neuron 65: 912-926. (Video abstract) 

47.Sun L, Wan H, Hu J, Han J, Matsunami H, and Luo MCA (2009) Guanylyl cyclase-D in the olfactory COneurons is activated by bicarbonate. PNAS 106: 2041-2046.

48.Qin C, Luo MCA (2009) Neurochemical phenotypes of the afferent and efferent projections of the mouse medial habenula. Neuroscience 161: 827-37 

49.Fan S, Luo MCA (2009) The organization of feedback projections in a pathway important for processing pheromonal signals. Neuroscience 161: 489-500

50.Yan Z, Tan J, Qin C, Lu Y, Ding C, and Luo MCA (2008) Precise circuitry links bilaterally symmetric olfactory maps. Neuron 58: 613–624. (Featured with a preview)

51.Bian X, Yanagawa Y, Chen WR, and Luo MCA (2008) Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala. J Neurophysiol 99: 77-86.

52.Luo MCA (2008) The Necklace Olfactory System in Mammals. J Neurogenetics 22: 229-238.

53.Hu J*, Zhong C*, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, and Luo MCA (2007) Detection of near-atmospheric concentrations of COby an olfactory subsystem. Science 317: 953-957. 

54.Grosmaitre X, Santarelli LC, Tan J, Luo M, and Ma MCA (2007) Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors. Nature Neurosci 10: 348-354.

Review

55.Liu Z, Lin R, Luo MCA (2020) Reward Contributions to Serotonergic Functions. Annual Review of Neuroscience. In press. 

56.Lin R, Yan T, Luo MCA (2019) The two faces of PVN CRF neurons. Nature Neuroscience doi:10.1038/s41593-019-0363-x.

57.Luo F, Wei Y, Wang Z, Luo M, Hu J (2019) Genetically encoded neural activity indicators. Brain Science Advances 4, 1-15. 

58.Luo F, Wei Y, Wang Z, Luo M, Hu JCA (2018) Genetically encoded neural activity indicators. Brain Science Advances 4(1): 1-15.

59.Lin RCA, Li Y, Luo M (2018) A Neural Circuit Driving Maternal Behaviors Neuron 98: 7-8, doi:10.1016/j.neuron.2018.03.025. 

60.Luo MCA, Li Y, Zhong W (2016) Do dorsal raphe 5-HT neurons encode “beneficialness”? Neurobiology of Learning and Memory doi:10.1016/j.nlm.2016.08.008. 

61.Luo MCA, Zhou, J, Liu Z (2015) Reward processing by the dorsal raphe nucleus: 5-HT and beyond. Learning Memory 22: 452-460. doi:10.1101/lm.037317.114.  

62.Luo MCA (2011) Long-range intracortical excitation shapes olfactory processing. Neuron 72: 1-3.  

63.Luo MCA, Sun L, and Hu J (2009) Neural detection of gases—carbon dioxide, oxygen—in vertebrates and invertebrates. Curr Opinion Neurobiol 19: 354-361. 

64.Luo MCA and Katz LC (2004) Encoding pheromones by the mammalian vomeronasal system. Curr Opinion Neurobiol 14: 428-34.