科学研究

Principal Investigators

Minmin Luo Ph.D

E-mail: luominmin@cibr.ac.cn; luominmin@nibs.ac.cn

Phone: +86 10 8072 3791

Lab Homepage:

Education

B.S. in Psychology, Beijing University,China, 1995

M.S. in Computer Science, University  of Pennsylvania, 1997

Ph.D. in Neuroscience, University of Pennsylvania, 2000

Professional Experience

03/2018 – present     Director and Investigator,

                                  Chinese Institute for Brain Research, Beijing(NIBS) ,Beijing, China

01/2013 – present     Investigator,

05/2010 – 12/2012    Associate Investigator,

10/2005 – present     Investigator and Laboratory Head,

10/2005 – 04/2010    Assistant Investigator and Director of Imaging Facility,

                                  National Institute of Biological Science,Beijing(NIBS) ,Beijing, China

03/2009 – present     Professor,

                                  School of Life Sciences, Tsinghua University(Tenured 5/2015), Beijing, China

08/2004 – 09/2005     Investigator and Laboratory Head

                                   Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

12/1999 – 70/2004    Postdoctoral Research (Advisor: Lawrence C. Katz)

                            Howard Hughes Medical Institute and Duke University, NC, USA

01/1997 – 12/1999     Ph.D. Thesis Research (Advisor: David J. Perkel)

                            Department of Neuroscience, University of Pennsylvania, PA, USA

Research Description

        Reward and Punishment are critical to animal survial and reproduction, and Have a great impact on our lives. To elucidate how neural circuit processes reward and punishment signals. I particularly focus on the functions and mechanisms of the brain 5-HT neurons in the dorsal raphe and the neural pathway from the medial habenula to the interpeduncular nucleus. My laboratory uses integrative approaches including electrophysiology, optical imaging and optogenetics, molecular genetics, and behavioral assays, and aims to revealing the role of the associated neural circuit at the molecular, cellular, physiological, and circuit levels. We also take the advantage of whole cell patch clamp and optical imaging to determine the cellular machanism and signal transduction pathways of drugs disturbing reward and punishment related behaviours  which get involved in human mental disorders, such as depression, sczhophrenia, and drug addiction. We expect to understand the basic neural circuits that control reward and punishment related behaviours, and also contribute to clincial treatment.  

Publications

1. Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi Z, Tang N, Shao F, Luo MCA (2018) A hybridizationchain-reaction-based method for amplifying immunosignals. Nature Methods doi:10.1038/nmeth.4611

2. Li Y, Zeng J, Zhang J, Yue C, Zhong W, Liu Z, Feng Q, Luo MCA (2018) Hypothalamic Circuits for Predation and EvasionNeuron 97, 911–924, doi:10.1016/j.neuron.2018.01.005. Featured with Cover and Video Abstract.

3. Ables JL, Görlich Antolin-Fontes B, Wang C, Lipford S, Riad MH, Ren J, Hu F, Luo M, Kenny PJ, Heintz N, Ibañez-Tallon, ICA(2017) A Retrograde inhibition by a specific subset of interpeduncular a5 nicotinic neurons regulates nicotine preference. PNASdoi:10.1073/pnas.1717506114

4. Zhong W, Li Y, Feng Q, Luo MCA (2017) Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons. J Neurosci 37, 8863-8875.

5. Wang D, Li Y, Feng Q, Guo Q, Zhou J, Luo MCA (2017) Learning shapes the aversion and reward responses of lateral habenula neurons. eLife 6:e23045

6. Zhao Z, Wang L, Gao W, Hu F, Zhang J, Ren Y, Lin R, Feng Q, Cheng, M, Ju D, Chi Q, Wang D, Song S, Luo M, Zhan CCA (2017) A central catecholaminergic circuit controls blood glucose levels during stress Neuron DIO: 10.1016/j.neuron.2017.05.031.

7. Luo J., Feng Q, Wei LCA, Luo MCA (2017) Optogenetic activation of dorsal raphe neurons rescues the autistic-like social deficits in Shank3 knockout mice. Cell Res DOI: 10.1038/cr.2017.52.

8. Huang L, Yuan T, Tan M, Xi Y, Hu Y, Tao Q, Zhao Z, Zheng J, Han Y, Xu F, Luo M, Sollars PJ, Pu M, Pickard GE, So K-FCA, Ren CCA (2017) A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behavior Nature Comms 8:14908 DOI:10.1038/ncomms14908.

9. Ren JCA, Zhang M, Li T, Zhang J, Lin R, Chen S, Luo M, Dong MCA (2016) Quantitative proteomics of sleep-deprived mouse brains reveals global changes in mitochondrial proteins. PLoS ONE 11 DOI:10.1371/journal.pone.0163500.

10Zhang J, Tan L, Ren Y, Liang J, Lin R, Feng Q, Zhou J, Hu F, Ren J, Wei C, Yu T, Zhuang Y, Bettler B, Wang F, Luo MCA (2016) Presynaptic excitation via GABAB receptors in habenula cholinergic neurons regulates fear memory expression. Cell 166:716–728 DOI: 10.1016/j.cell.2016.06.026.

11. Hu L, Zhang J, Luo M, Hu JCA (2016) Response patterns of GABAergic neurons in the anterior piriform cortex of awake mice. Cerebral Cortex doi: 10.1093/cercox/bhw175.

12. Glajch K, Kelver D, Hegeman D, Cui Q, Xenias H, Augustine E, Hernandez V, Verma N, Huang T, Luo M, Justice N, Chan SCA (2016) Npas1+ pallidal neurons target striatal projection neurons. J Neurosci 36 (20) 5472-5488.

13.  Li Y, Zhong W, Wang D, Feng Q, Liu Z, Zhou J, Jia C, Hu F, Zeng J, Guo Q, Fu L, Luo MCA (2016) Serotonin neurons in the dorsal raphe nucleus encode reward signals. Nature Comms 7:10503 doi: 10.1038/ncomms10503.

14.  Guo Q*, Zhou J*, Feng Q, Lin R, Gong H, Luo Q, Zeng S, Luo MCA, Fu LCA (2015) Multi-channel fiber photometry for population neuronal activity recording. Biomedical Optics Express 6:3919-3931. doi: 10.1364/BOE.6.003919.

15.  Soria-Gómez E, Busquets-Garcia A, Hu F, Mehidi A, Cannich A, Roux L, Louit I, Alonso L, Wiesner T, Georges F, Verrier D, Vincent P, Ferreira G, Luo M, Marsicano GCA (2015) Habenular CB1 receptors control the expression of aversive memories. Neuron 88:306-13. doi: 10.1016/j.neuron.2015.08.035.

16.  Wang D, He X, Zhao Z, Feng Q, Lin R, Sun Y, Ding T, Xu FCA, Luo MCA, Zhan CCA  (2015) Whole-brain mapping of the direct inputs and axonal projections of pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons. Front. Neuroanat. DOI 10.3389/fnana.2015.00040.

17.  Guo Q, Wang D, He X, Feng Q, Lin R, Xu F, Fu L, Luo MCA (2015) Whole-brain mapping of inputs to projection neurons and cholinergic interneurons in the dorsal striatum. PLoS ONE DOI: 10.1371/journal.pone.0123381.

18.  Zhou J, Jia C, Feng Q, Bao J, Luo MCA (2015) Prospective coding of dorsal raphe reward signals by the orbitofrontal cortex. J Neurosci 35:2717-2730.

19.  Liu Z*, Zhou J*, Li Y, Hu F, Wang D, Lu Y, Ma M, Feng Q, Zhang J, Zeng J, Bao, Kim J, Chen Z, Mestikawy SE, Luo MCA (2014) Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron 81:1360–1374. (F1000 recommendation)

20.  Han Y, Shi Y-F, Xi W, Zhou R, Tan Z-B, Wang H, Li X-M, Chen Z, Feng G, Luo M, Huang Z-L, Duan SCA, Yu Y-QCA (2014) Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions. Current Biology 24:693–698

21.  Wang S, Tan Y, Zhang J,Luo MCA (2013) Pharmacogenetic activation of midbrain dopamine neurons induces hyperactivity. Neurosci Bulletin 29:517-524.

22.  Zhan CCA, Zhou J, Feng Q, Zhang J, Lin S, Bao J, Wu P, Luo MCA (2013) Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci 33:3624 –3632. (F1000 recommendation)

23.  Hu F, Ren J, Zhang J, Zhong W, Luo MCA (2012) Atrial natriuretic peptide blocks synaptic transmission by activating Phosphodiesterase 2A and eliminating basal PKA activity in presynaptic terminals. PNAS 109: 17681–17686. (F1000 recommendation)

24Ma M, Luo MCA (2012) Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb. J Neurosci 32:10105-10116. (TWIJ feature article).

25.  Gong R*, Ding C*, Hu J*, Lu Y, Liu F, Mann E, Xu F, Cohen MB and Luo MCA (2011) Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333:1642-1646.

26.  Zhao S, Ting JT, Atallah HE, Qiu L, Tan J, Gloss B, Augustine GJ, Deisseroth K, Luo M,  Graybiel AM, Feng GCA (2011) Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nature Methods 8:745-752.

27.  Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S, Feng G, Luo MCA (2011) Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron 69:445-452. (Cover; F1000 recommendation)

28.  Zhan C, Luo MCA (2010) Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neurosci 30:16662–16672.

29.  Han J, Luo MCA (2010) Loss of CO2 sensing by the olfactory system of CNGA3 knockout mice. Curr Zoology 56: 793−799.

30.  Gao L, Hu J, Zhong C, Luo MCA (2010) Integration of CO2 and odorant signals in the mouse olfactory bulb. Neuroscience 170:881–892.

31.  Tan J, Savigner A, Ma M, and Luo MCA (2010) Odor information processing by the olfactory bulb analyzed in gene-targeted mice. Neuron 65:912-926. (Video abstract)

32.  Sun L, Wan H, Hu J, Han J, Matsunami H, and Luo MCA (2009) Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. PNAS 106:2041-2046.

33.  Qin C, Luo MCA (2009) Neurochemical phenotypes of the afferent and efferent projections of the mouse medial habenula. Neuroscience 161:827-37

34.  Fan S, Luo MCA (2009) The organization of feedback projections in a pathway important for processing pheromonal signals. Neuroscience 161:489-500

35.  Yan Z, Tan J, Qin C, Lu Y, Ding C, and Luo MCA (2008) Precise circuitry links bilaterally symmetric olfactory maps. Neuron 58:613–624. (Featured with a preview)

36.  Bian X, Yanagawa Y, Chen WR, and Luo MCA (2008) Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala. J Neurophysiol 99:77-86.

37.  Luo MCA (2008) The Necklace Olfactory System in Mammals. J Neurogenetics 22:229-238.

38.  Hu J*, Zhong C*, Ding C, Chi Q, Walz A, Mombaerts P, Matsunami H, and Luo MCA (2007) Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem. Science 317:953-957.

39.  Grosmaitre X, Santarelli LC, Tan J, Luo M, and Ma MCA (2007) Dual functions of mammalian olfactory sensory neurons as odor detectors and mechanical sensors. Nature Neurosci 10: 348-354.

40.  Luo, MCA, Fee, MS, and Katz, LC (2003) Encoding pheromonal signals in the accessory olfactory bulb of behaving mice. Science 299:1196-1201 (article, cover, and News and Views; Faculty 1000 recommendation).

41.  Luo, M and Perkel, DJ (2002) Intrinsic properties and synaptic input for neurons within an avian motor thalamic nucleus during the phase crucial for song learning. J Neurophysiol 88:1903-1914.

42.  Perkel, DJ, Farries, MA, Luo, M, and Ding, L (2002) Electrophysiological analysis of a songbird basal ganglia circuit essential for vocal plasticity. Brain Res Bulletin 57:529-532.

43.  Luo, MCA and Katz, LC (2001) Response correlation maps of neurons in the mammalian olfactory bulb. Neuron 32:1165-1179.

44.  Luo, M, Ding, L, and Perkel, DJ (2001) An avian basal ganglia pathway essential for vocal learning forms closed topographic loops. J Neurosci 21:6836-45.

45.  Luo, M, and Perkel, DJ (1999) A GABAergic, strongly inhibitory projection to a thalamic nucleus in the zebra finch song system. J Neurosci 19:6700-11.

46.  Luo, M, and Perkel, DJ (1999) Long-range GABAergic projection in a circuit essential for vocal learning. J Comp Neurol 403: 68-84.

Reviews:

47.  Lin RCA, Li Y, Luo M (2018) A Neural Circuit Driving Maternal Behaviors Neuron 98:7-8 https://doi.org/10.1016/j.neuron.2018.03.025.  

48.  Luo MCA, Li Y, Zhong W (2016) Do dorsal raphe 5-HT neurons encode “beneficialness”? Neurobiology of Learning and Memory; DOI: 10.1016/j.nlm.2016.08.008.

49.  Luo MCA, Zhou, J, Liu Z (2015) Reward processing by the dorsal raphe nucleus: 5-HT and beyond. Learning Memory 22:452-460. DOI: 10.1101/lm.037317.114. 

50.  Luo MCA (2011) Long-range intracortical excitation shapes olfactory processing. Neuron 72:1-3. 

51.  Luo MCA, Sun L, and Hu J (2009) Neural detection of gases—carbon dioxide, oxygen—in vertebrates and invertebrates. Curr Opinion Neurobiol 19354-361.

52.  Luo, MCA. (2004) Got milk? A pheromonal message for newborn rabbits. Bioessays 26:6-9.

53.  Luo, MCA and Katz LC (2004) Encoding pheromones by the mammalian vomeronasal system. Curr Opinion Neurobiol 14:428-34.