科学研究

Principal Investigators

Ying Li Ph.D.

E-mail: liying@@cibr.ac.cn/yingli820@@gmail.com(remove one@ when use it)

Phone:

Lab Homepage:

Education

B.S in Biology, Nanjing University, Nanjing, China (2003.9-2007.7)

Ph.D. in Neuroscience, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China (2007.9-2013.3)


Professional Experience

2013.4 - 2019.7 Postdoctoral fellow, Catherine Dulac lab, HHMI, Harvard University, USA

2019.8 – present  Assistant  Investigator, Chinese Institute for Brain Research, CIBR, Beijing, China 



Honors-Awards

2020  Qiushi Science and Technology Foundation, Outstanding Young Investigator Award

2019  Beijing Nova Program of Science and Technology

2019  Human Frontier Science Program, Career Development Award

2018  Harvard Chinese Life Science Annual Distinguished Research Award

2014-2017  Human Frontier Science Program, Long-term Postdoc Fellowship

2013  Chinese Academy of Sciences presidential prize

2013  Ray Wu prize



Research Description

A long-sought goal in neuroscience is to understand how the nervous system interprets salient information from the external world and generate appropriate behaviors. In social environments, individual interests may be conflicted with the needs and expectations of others. Thus, the ability to respond adequately to social stimuli is critical for facilitating adaptive behaviors that are directed at increasing reproduction and survival. Although most animals are capable of adjusting social behaviors depending on their internal states and the expectations of encounters, we are only beginning to understand the underlying neural circuits and mechanisms that mediate the formation and the plasticity of adaptive social behaviors. Combining multi-disciplinary approaches including microendoscope-based calcium imaging, single-cell sequencing, optogenetics, photometry, in vivo and ex vivo electrophysiology and pharmacology approaches, my laboratory aims to understand the underlying neural circuits that mediate the processing of environmental social stimuli.

Where are the neurons specifically involved in coordinating changes of internal states to generate adaptive behavioral responses? Which neural circuits are responsible for assigning emotional values (i.e., positive and negative) to environmental social cues? How are these circuits regulated by the activity of multiple neuromodulation systems? Whether individuals perceive themselves and others differently in young and adult? If so, what is the developmental trajectory and how does it shape by experience? Answering these questions will enable us to understand the nature of neural circuit dynamics that contribute to adaptive behaviors and lead to the development of novel treatments to social deficits in neuropsychiatric disorders. 


Publications

1. Li, Y. and Dulac, C.* (2018). Neuronal coding of sex-specific social information in the mouse brain. Curr Opin Neurobiol 53, 120-130 (Cover).

2. Li, Y., Mathis A., Benjamin GF., Osterhout J., Ahanonu B.,Schnizter M.,Venkatesh N and Dulac C* (2017). Neuronal representation of social information in the medial amygdala of behaving mice. Cell 171(5), 1176-1190.

3. Li, Y., Du, X.F., and Du, J.L.* (2013). Resting microglia respond to and regulate neuronal activity in vivo. Communicative & Integrative Biology. 6: e24493

4. Li, Y.,# Du, X.F.,# Liu, C.S., Wen, Z.L., and Du, J.L.* (2012). Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Developmental Cell 23, 1189-1202. (# co-first authors)  (Highlighted by Preview in Developmental Cell 23, 1125-1126; and Faculty of 1000; Recommended by NEURON in 2013 as one of most influential papers of microglia research field in the last two years).

5. Xiao, H.,# Li, Y.,# Du, J.L.*, and Mosig, A.* (2011). Ct3d: tracking microglia motility in 3D using a novel co-segmentation approach. Bioinformatics 27, 564-571. (# co-first authors)