科学研究

Principal Investigators

Wenzhi Sun Ph.D

E-mail: sunwenzhi@cibr.ac.cn

Phone: 010-62756185

实验室主页:

Education

2004 Doctor of Philosophy in Neuroscience (Advisor: Dr. Shigang He), Institute of Neuroscience (ION), Chinese Academy of Sciences, Shanghai, China

1999 Bachelor of Science in Marine Biology, Ocean University of China (OUC), Qingdao, Shandong, China


Professional Experience


2018-present      Principal Investigator

Chinese Institute for Brain Research, CIBR, Beijing, China

Sept 2016 -2018  Associate Research Professor

iHuman Institute, ShanghaiTech University, Shanghai, China

May.2012 – Sept 2016 Research Specialist (Na Ji Lab)
HHMI Janelia Research Campus, Ashburn VA, USA

Nov.2010 – May.2012 Associate Research Scientist (Wayne N Frankel Lab)
     the Jackson Laboratory, Bar Harbor ME, USA

Dec.2004 – Oct.2010 Postdoc Fellow/Research Associate (Yang Dan Lab)
     University of California, Berkeley/HHMI, Berkeley CA, USA


Research Description
Publications

1. Richie CT, Whitaker LR, Whitaker KW, Necarsulmer J, Baldwin HA, Zhang Y, Fortuno L, Hinkle JJ, Koivula P, Henderson MJ, Sun W, Wang K, Smith JC, Pickel J, N Ji, Hope BT, Harvey BK (2017), Near-infrared fluorescent protein iRFP713 as a reporter protein for optogenetic vectors, a transgenic Cre-reporter rat, and other neuronal studies. Journal of Neuroscience Methods, 284, 1-14

2. Lu R, W Sun, Liang Y, Kerlin A, Bierfeld J, Seelig J, Wilson V, Scholl B, Mohar B, Tanimoto M, Koyama M, Fitzpatrick D,Orger MB, Ji N (2017), Video-rate volumetric functional imaging of the brain at synaptic resolution. Nature Neuroscience, 20, 620-628.

3. Sun W, Tan Z, Mensh BD & Ji N (2016), Thalamus provides layer 4 of primary visual cortex with tuned inputs. Nature Neuroscience, 19, 308-315.

Highlighted by HHMI Research News (https://www.hhmi.org/news/adaptive-optics-helps-reveal-what-eyes-tell-brain)

4. Tan Z, Sun W, Chen TW, Kim D & Ji N (2015) Stimulus Feature Selectivity for Ultraviolet Light in Mouse Primary Visual Cortex.  Scientific Reports, 5: 12597. doi: 10.1038/srep12597.

5. Wang K#, Sun W#, Richie CT, Harvey BK, Betzig E & Ji N (2015), Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue. Nature Communications, 6:7276. doi: 10.1038/ncomms8276. (# Co-first-author)

6. Wang C, Liu R, Milkie DE, Sun W , Tan Z, Kerlin A, Chen TW, Kim DS & Ji N (2014) Multiplexed aberration measurement for deep tissue imaging in vivo. Nature Methods, 11: 1037–1040

7. Sun W, Wagnon JL, Mahaffey CL, Briese M, Ule J & Frankel WN (2013) Aberrant Sodium Channel Activity in the Complex Seizure Disorder of Celf4 Mutant Mice. Journal of Physiology, 591:241-255, (Highlighted in Future Neurology, 8(3):255-257, DOI 10.2217/fnl.13.13)

8. Wagnon JL, Briese M, Sun W, Mahaffey CL, Li Y, Curk Y, Rot G, Lin D, Ule J & Frankel WN (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genetics, 8 (11), e1003067

9. Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT & Frankel WN (2011) Etiology of a Genetically Complex Seizure Disorder in Celf4 Mutant Mice. Gene, Brain and Behavior, 10:765-777

10. Sun W & Dan, Y (2009) Layer-Specific Network Oscillation and spatiotemporal Receptive Field in the Visual Cortex, Proceedings of the National Academy of Sciences, 106:17986-17991.

11. Sun W#, Deng Q# & He S (2006), ON direction-selective ganglion cells in the mouse retina. Journal of Physiology, 576:197-202. (# Co-first-author)

12. Weng S, Sun W & He S (2005) Identification of ON-OFF direction-selective ganglion cells in the mouse retina. Journal of Physiology, 562: 915 – 923.

13. Diao L, Sun, W Deng Q & He S (2004) Development of the mouse retina: emerging morphological diversity of the ganglion cells. Journal of Neurobiology, 61: 236-249.

14. Dong W, Sun W, Zhang Y, Chen X & He S (2004) Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina. Journal of Physiology, 556: 11-17.

15. He S, Dong W, Deng Q, Weng S & Sun W (2003) Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry. Science, 302:408-411. (Review)

16. Sun W, Li N & He S (2002) Large-scale morphological survey of rat retinal ganglion cells. Visual Neuroscience, 19:483-493. 

17. Sun W, Li N & He S (2002) Large-scale morphological survey of mouse retinal ganglion cells. Journal of Comparative Neurology, 451:115-126.