科学研究

Principal Investigators

Jian Chen Ph.D.

E-mail:

Phone: 010-62756185

Lab Homepage:

Education

2004 – 2011 UTsouthwestern Medical Center at Dallas, Genetics & Development, PhD, Postdoc

1999 – 2003 Peking University, Collage of Life Sciences, Bachelor


Professional Experience

2019-present  Assistant  Investigator,Chinese Institute for Brain Research, CIBR, Beijing, China

2014 – 2019  Professor,Soochow University, Institute of Functional Nano and Soft Materials,

2012 – 2014  Director,Origene Technologies, Senior Scientist



Research Description

Glioblastoma is one of the most malignant tumors, and after decades of research, treatment regimens for glioma patients are still limited to surgery, radiotherapy and chemotherapy regimens, while the survival of glioblastoma patients is still only more than 10 months old. Our previous studies have shown that gliomas are likely to originate from adult neural stem cells that have the ability to renew themselves. In an established malignant glioma, there are some tumor cells that express stem cell markers, which are very important for the tumor’s resistance to chemotherapy and tumor recurrence.

By utilizing mouse genetics, primary (tumor) cell culture, we are trying to understand key components that drives malignant transformation or responsible for tumor maintenance. We are also interested in the unique relationship between the immune system and brain microenvironment. Meanwhile, we are exploring the use of small molecules, CAR-T and tumor lytic virus for tumor progression intervention.


Publications

1. Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J#, Parada LF# (2014).NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev. 28(21) : 2407-20 . (# Corresponding author)

2. Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF (2012). A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 488(7412):522-6.

3. Chen J, Mckay RM, Parada LF (2012). Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell. 30;149(1):36-47.

4. Alcantara Llaguno S*, Chen J*, Kwon CH*, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF (2009). Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 15:45-56. (, Authorship equally shared)

5. Wang P*, Chen J*, Zheng A*, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H (2004). Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun. 315:439-44. (,Authorship equally shared)