科学研究

Principal Investigators

Tongfei A. Wang Ph.D.

E-mail: wangtongfei@@cibr.ac.cn(remove one @ when use it)

Phone:

Lab Homepage:

Education

2005-2012  Ph.D. in Molecular and Integrative Physiology

                  University of Illinois at Urbana-Champaign

2001-2005  B.S. in Biological Science

                  Peking University


Professional Experience

2020-present  Assistant  Investigator

                        Chinese Institute of Brain Research, Beijing

2012-2020      Postdoc Scholar

                        University of California, San Francisco   


Research Description

The Wang lab is interested in the homeostatic regulation of metabolism-related physiology and behaviors. Our current research focuses on dissecting the neural circuitry of anterior hypothalamus in rodents, with two major directions studying 1) the body temperature control mediated by the preoptic area and 2) the circadian clock mediated by the suprachiasmatic nucleus. Our long-term goal aims towards the mechanistic understanding of mammalian hibernation and its potential application in clinics.

The research in the Wang lab is oriented by scientific questions, but not certain technique. Modern neuroscience research emphasizes the integration of multidisciplinary approaches; we thus employ diverse set of experimental strategies in our research programs, including but not limited to electrophysiology, real-time imaging, optogenetics, neuronal tracing, single-cell RNA-seq, mass-spec, and animal behavior analysis. We are also actively involved in developing novel technology for neuroscience research.


Publications

1. Wang, T.A., Teo, C.F., Akerblom, M., Chen, C., Diaz, A., McManus, M.T., Jan, Y.N., Jan, L.Y. (2019) Thermoregulation via Temperature-dependent PGD2 Production in Mouse Preoptic Area. Neuron. 103: 309–322. PMID: 31151773. (Featured by previews in Neuron and Nat Rev Neurosci)

2. Huang, X., He, Y., Dubuc, A.M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T.A., Stehbens, S.J., Younger, S., Barshow, S., Zhu, S., Cooper, M.K., Peacock, J., Ramaswamy, V., Garzia, L., Wu, X., Remke, M., Forester, C.M., Kim, C.C., Weiss, W.A., James, C.D., Shuman, M.A., Bader, G.D., Mueller, S., Taylor, M.D., Jan, Y.N., Jan, L.Y. (2015) EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 18(9):1236-46. PMID: 26258683.

3. Feenstra, B., Pasternak, B., Geller, F., Carstensen, L., Wang, T., Huang, F., Eitson, J.L., Hollegaard, M.V., Svanström, H., Vestergaard, M., Hougaard, D.M., Schoggins, J.W., Jan, L.Y., Melbye, M., Hviid, A. (2014) Common variants associated with general and MMR vaccine–related febrile seizures. Nat Genet. 46(12):1274-82. PMID:25344690. (Featured by previews in Nat Genet)

4. Rajashekar, I., Wang, T.A., Gillette, M.U. (2014) Circadian gating of neuronal functionality: a basis for iterative metaplasticity. Frontiers in Systems Neuroscience. 8: 164.  PMID: 25285070.

5. Gillette, M.U., Wang, T.A.. (2014). Brain Circadian Oscillators and Redox Regulation in Mammals. Antioxidants & Redox Signaling (Invited Forum Review). 20(18):2955-65.  PMID: 24111727.

6. Govindaiah, G., Wang, T., Gillette M.U., Cox, C.L. (2012). Activity-dependent regulation of retinogeniculate signaling by metabotropic glutamate receptors. J Neurosci. 32(37):12820-31. PMID: 22973005.

7. Wang, T.A., Yu, Y.V., Govindaiah, G., Ye, X., Artinian, L., Coleman, T., Sweedler, J.V., Cox,  C.L., Gillette, M.U. (2012). Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons. Science. 337 (6096): 839-842. PMID: 22859819. (Featured by previews in Science and Sci Signal)

8. Govindaiah, G., Wang, T., Gillette, M.U., Crandall, S.R., Cox C.L. (2010). Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus. J Neurophysiol. 104(5): 2757-2765. PMID: 20884758.

9. Wang, T., Zhou, C., Tang, A., Wang, S., Chai, Z. (2006). Cellular Mechanism for Spontaneous Calcium Oscillations in Astrocytes. Acta Pharmacologica Sinica. 27 (7): 861–868. PMID: 16787570.