科学研究

Principal Investigators

Joji Tsunada D.V.M.、Ph.D.

E-mail: jtsunada@@cibr.ac.cn(remove one@ when use it)

Phone:

Lab Homepage: http://www.tsunada-lab.org/

Education

1998-2004     Doctor of Veterinary Medicine, 

                       Hokkaido University School of Veterinary Medicine, Japan

2004-2008     Doctorate, 

                       Hokkaido University Graduate School of Medicine, Japan (Advisor: Toshiyuki Sawaguchi & Kikuro Fukushima)


Professional Experience

2008.4-2008.8     Postdoctoral Research Fellow, Department of Psychology, 

                            Tokyo Metropolitan Institute for Neuroscience, Japan (Advisor: Masataka Watanabe)

2008.9-2009.3     Postdoctoral Research Fellow, Department of Psychological & Brain Sciences, 

                            Center for Cognitive Neuroscience, Dartmouth College, USA (Advisor: Yale E. Cohen)

2009.4-2015.6     Research Associate, Department of Otorhinolaryngology: Head and Neck Surgery, 

                            University of Pennsylvania School of Medicine, USA (Advisor: Yale E. Cohen)

2015.7-2019.2     Research Associate, Department of Otorhinolaryngology: Head and Neck Surgery, 

                            University of Pennsylvania School of Medicine, USA (Advisor: Steven J. Eliades)

2019.3-2020.2     Research Assistant Professor, Department of Veterinary Medicine, 

                            Iwate University, Japan

2019.3-                Visiting Scientist, Department of Otorhinolaryngology: Head and Neck Surgery, 

                            University of Pennsylvania School of Medicine, USA

2020.3-                Assistant  Investigator, 

                            Chinese Institute for Brain Research, Beijing, China


Research Description

We have been tackling a challenge in auditory neuroscience: bridging a gap between our understanding of primate auditory behaviors and their neural mechanisms. Previous work focused on neural mechanisms of task-trained auditory behaviors, auditory categorization and perceptual decision-making (Tsunada et al., 2011, 2012, 2016, 2019). We recently started studying naturalistic auditory behavior, vocal communication (Eliades and Tsunada, 2018; Tsunada and Eliades, 2020).

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In the Tsunada Laboratory, we aim to reveal the behavioral and neural mechanisms of vocal communication and its disorders. Vocal communication plays an important role in maintaining group cohesion and social bonds of both humans and many animal species. A key feature of human conversational communication, however, is our ability to flexibly modify and control our speech depending upon the communicative context, taking into account recent history, conversational contents, as well as the specific speakers and listeners involved. Despite a long history of behavioral and neural studies on vocal communication, it remains poorly understood what behavioral and neural mechanisms enable us to control vocal interactions according to the communicative context. We aim to demonstrate the underlying behavioral and neural mechanisms of normal social vocal communication using a highly vocal primate species, marmoset monkey. A better understanding of the mechanisms of normal vocal communication will inform our understanding of how and why patients with mental (e.g., schizophrenia) or developmental (e.g., autism spectrum disorder) disorders have problems in vocal communication, thereby contributing to develop new therapeutic approaches to improve their communication.

Publications

Research reports

1. Tsunada J., and Eliades S.J.* (2020) Dissociation of unit activity and gamma oscillations during vocalization in primate auditory cortex. Journal of Neuroscience

2. Tsunada J., Cohen Y.E.*, and Gold J.I. (2019) Post-decision processing in primate prefrontal cortex influences subsequent choices on an auditory decision-making task. eLIFE 8(e46770)

3. Eliades S.J.* and Tsunada J. (2018) Auditory cortical activity drives feedback-dependent vocal control in marmosets. Nature Communications 9:2540

[selected as an F1000Prime paper by Dr. Alan Palmer and Dr. Christian John Sumner]

4. Tsunada J., Liu A.S., Gold J.I., and Cohen Y.E.* (2016) Causal contribution of primate auditory cortex to auditory perceptual decision-making. Nature Neuroscience 19(1):135-142

[selected as an F1000Prime paper by Dr. Andrew King]

5. Johnston J.M., Cohen Y.E., Shirley H., Tsunada J., Bennur S., Christison-Lagay K., and Veeder C.L.* (2016) Recent Refinements to Cranial Implants in Rhesus Macaques (Macaca mulatta). Lab Animal 45(5):180-186

6. Liu A.S., Tsunada J., Gold J.I., and Cohen Y.E.* (2015) Temporal integration of auditory information is invariant to temporal grouping cues. eNeuro 2(2)

Lee J.H.*, Tsunada J., and Cohen Y.E. (2013) A model of the differential representation of signal novelty in the local field potentials and spiking activity of the ventrolateral prefrontal cortex. Neural computation 25(1):157-85.

7. Tsunada J.*, Lee J.H., and Cohen Y.E. (2012) Differential representation of auditory categories between cell classes in primate auditory cortex. Journal of Physiology 509(13):3129-39.

8. Tsunada J.*, and Sawaguchi T. (2012) Neuronal categorization and discrimination of social behaviors in primate prefrontal cortex. Plos One e52610.

9. Tsunada J.*, Baker A.E., Christison-Lagay K.L., Davis S.J., and Cohen Y.E. (2011) Modulation of cross-frequency coupling by novel and repeated stimuli in the primate ventrolateral prefrontal cortex. Frontiers in Psychology 2:217.

10. Tsunada J., Lee J.H., and Cohen Y.E.* (2011) Representation of speech categories in the primate auditory cortex. Journal of Neurophysiology 105(6):2634-46.

[Commentary by Steinschneider M. (2011) Unlocking the role of the superior temporal gyrus for speech sound categorization Journal of Neurophysiology 105(6):2631-3.] 

Reviews

1. Cohen Y.E.*, Bennur S., Christison-Lagay K., Gifford A.M., and Tsunada J. (2016) Functional Organization of the Ventral Auditory Pathway. Advances in Experimental Medicine and Biology 894:381-8.

2. Tsunada J.*, and Cohen Y.E. (2014) Neural mechanisms of auditory categorization: from across brain areas to within local microcircuits. Frontiers in Neuroscience 8:161.

3. Bennur S.†, Tsunada J.†, Cohen Y.E., and Liu R.C.* (2013) Understanding the neurophysiological basis of auditory abilities for social communication: A perspective on the value of ethological paradigms. Hearing Research 305:3-9.

4. Cohen Y.E.*, Lee J.H., Tsunada J., and Russ B.E. (2009) Auditory categories in the non-human primate. Handbook of Mammalian Vocalization.

*Corresponding author

† Equal contribution