科学研究

Seminars

Critical Period in the Development of the Sense of Smell: Mechanisms and Behavioral Consequences

2019-07-17

Seminar Type

B-type

Preferred Location

First Floor Lecture Hall, Jianzan Building (Phase I)Chinese Institute for Brain Research, Beijing

Time

10:30-11:30 am Friday,July 19, 2019 

Speaker:

Congrong “Ron” Yu, Ph.D

Investigator

Stowers Institute for Medical Research

Associate Professor

Department of Anatomy & Cell Biology
The University of Kansas School of Medicine

Host

Dr. Minmin Luo

Topic

Critical Period in the Development of the Sense of Smell: Mechanisms and Behavioral Consequences

Abstract

The critical period is a developmental window during which sensory experience have lasting impact on the anatomical connection and functions of neural circuits. In the mammalian species, the olfactory system is the only nervous system that continuously generate new neurons throughout the life of the animals. This unique characteristic suggests that the olfactory neurons may hold a secret of regenerative capacity that is lost in other neurons. In this regenerative nervous system, we discover a critical period in setting up the highly specific connections between sensory neurons and their central targets. Despite massive neurogenesis during the postnatal development, we found only a population of perinatally born sensory neurons are endowed with the ability to set the olfactory map, and to correct erroneously projecting axons. Here I will discuss the behavioral implication of a critical period in the olfactory system development, the identification of a population of navigator neurons during the critical period, the cellular mechanisms by which the navigators establish the olfactory map, and the molecular mechanism that control the timing of the critical period