科学研究

Seminars

Illuminating spatial learning and memory neural circuits in health and disease

2019-08-30

Seminar Type

B-type


Preferred Location

Third Floor Lecture Hall, Jianzan Building (Phase I)

Chinese Institute for Brain Research, Beijing


Time

10:00-11:00  Monday,September 2nd , 2019


Speaker

Xiangmin Xu, Ph.D.

Professor

Department of Anatomy and Neurobiology

School of Medicine

University of California, Irvine


Host

Dr. Fei Zhao


Topic

Illuminating spatial learning and memory neural circuits in health and disease


Abstract

applications of the latest technologies of neuroscience in mapping hippocampal neural circuits related to spatial learning and memory. He will discuss insights from their studies of cortico-hippocampal circuitry associated with subiculum (SUB) projections to CA1.  Specifically, their recent work has identified a distinct sub-population of SUB neurons forming a pathway from visual cortex to CA1 and perirhinal cortex, and demonstrated that this pathway plays a critical role in object-place learning.  These findings in hippocampal circuit mechanisms provide an intriguing new target to counteract Alzheimer's Disease (AD)-related memory impairments.  The Xu lab is currently working to determine whether spatial memory can be rescued by patterned stimulation of the non-canonical subiculum-CA back-projection in AD model mice.


Speaker Biography

Education 

08/1998-02/2004      Ph.D., Psychology/Neuroscience, Vanderbilt University

09/1995-06/1998      M.S., Neurobiology, Shanghai Institute of Physiology, Chinese Academy of Sciences

09/1990-06/1995        Bachelor of Medicine, Shanghai Medical University, Shanghai China

Research Statement

I have a strong background in biology, engineering and medicine that I have applied to answering fundamental questions in neuroscience.  My interests focus on neural circuit organization and function, in relation to the neurobiology of sensory perception, learning and memory, and stress.  We use a multidisciplinary approach that combines electrophysiology, photostimulation and optical imaging, molecular genetics and viral tracing.  Our analysis is further refined and informed by engineering and computational techniques.  Our achievements are reflected by our publications in high impact journals, and my receipt of prestigious awards as an independent investigator.  I have been a Principal Investigator for multiple NIH and private foundation grants.  I have active collaborations with many other successful investigators at UC Irvine and at other major research institutions in southern California and elsewhere in the US.