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Facilities

Core Facilities

Wenlong Li Ph.D Director of Laboratory Animal Resource Center

E-mail: liwenlong@cibr.ac.cn

Phone:

Lab Homepage:

Education

2007.09-2010.06 National Center of Biomedical Analysis, cell biology, (Ph.D student)                                                   

2002.09-2005.06 Institute of JingFeng Medical Laboratory Animal, preventive veterinary medicine, (Graduate student);

1995.09-1999.07 Jilin University (current), veterinary public health, (Bachelor student)



Professional Experience

2019-present Chinese Institute for Brain Research, Director of Laboratory Animal Resource Center

1999-2019 Institute of JingFeng Medical Laboratory Animal


Research Description

Laboratory Animal Resource Center (LARC) provides animal related technical service for scientists., such as holding and breeding of laboratory animal, purification of laboratory animal, cryopreservation and recovery of embryo and sperm, quality testing, behavior testing and animal model of diseases.

The first phase of laboratory animal facilities (barrier environment) covers an area of 1400 square meters. The facility is equipped with individually ventilated cages, cage & rack washer, cabinet washer, bottle system, pulsating vacuum sterilizer, cage changing station,high-throughput xenon ray pass box, biological safety cabinet and other feeding related equipment. The experimental functional area is equipped with stereotaxic apparatus, small animal anesthesia machine, living animal imaging instrument and other equipment. LARC exists to promote animal welfare and use in support of CIBR’s research goals through compliance with the Institutional Animal Care and Use Committee. 

Publications

 1. Yang, L., Li, W., Liu, B., Wang, S., Zeng, L., Zhang, C., and Li, Y. (2016) iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle. Archives of dermatological research 308, 503-510.

2. Wenlong, L., Leilei, Y., Wei, F., Yi, C., Jing, T., Lanzhi, M., Bing, L., Yang, L., Shaoxia, W., Qiuxia, F., Zeliang, C., and Zengming, Z. (2015) Luciferase expression is driven by the promoter of fibroblast activation protein-a in murine pulmonary fibrosis. Biotechnology letters 37, 1757-1763.

3. Liu, B., Xu, Y., Li, W. L., and Zeng, L. (2015) Proteomic analysis of differentially expressed skin proteins in iRhom2(Uncv) mice. BMB reports 48, 19-24.

4. Leilei, Y., Bing, L., Yang, L., Shaoxia, W., Yuan, X., Dongping, W., Huahu, Y., Shichen, S., Guangzhou, Z., Ruiyun, P., Lin, Z., and Wenlong, L. (2014) iRhom2 mutation leads to aberrant hair follicle differentiation in mice. PloS one 9, e115114.

5. Ke, Y., Zhen, Q., Wang, Y., Yuan, X., Li, W., Lu, Y., Qiu, Y., Yu, Y., Huang, L., and Chen, Z. (2013) Window of treatment initiation for human brucellosis, implications for treatment efficacy, and prevention of chronic infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 56, 1350-1352.

6. Yang, L., Li, W., Wang, S., Wang, L., Li, Y., Yang, X., and Peng, R. (2012) Smad4 disruption accelerates keratinocyte reepithelialization in murine cutaneous wound repair. Histochemistry and cell biology 138, 573-582.

7. Tan, X., Weng, T., Zhang, J., Wang, J., Li, W., Wan, H., Lan, Y., Cheng, X., Hou, N., Liu, H., Ding, J., Lin, F., Yang, R., Gao, X., Chen, D., and Yang, X. (2007) Smad4 is required for maintaining normal murine postnatal bone homeostasis. Journal of cell science 120, 2162-2170.

8. Lan, Y., Liu, B., Yao, H., Li, F., Weng, T., Yang, G., Li, W., Cheng, X., Mao, N., and Yang, X. (2007) Essential role of endothelial Smad4 in vascular remodeling and integrity. Molecular and cellular biology 27, 7683-7692.

9. Yang, L., Mao, C., Teng, Y., Li, W., Zhang, J., Cheng, X., Li, X., Han, X., Xia, Z., Deng, H., and Yang, X. (2005) Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer research 65, 8671-8678.

10. Zhang, J., Tan, X., Li, W., Wang, Y., Wang, J., Cheng, X., and Yang, X. (2005) Smad4 is required for the normal organization of the cartilage growth plate. Developmental biology 284, 311-322.