Jie Yin

GPCRs are the primary receptors for hormones, neurotransmitters, and the senses of vision, smell, and taste. Given their roles in regulating nearly all aspects of human physiology, GPCRs are targets of about 1/3 of pharmaceuticals in the market. Therefore, obtaining atomic structural information of receptors helps understand the ligand binding and activation mechanism at the molecular level and aids the rational discovery and development of candidate drugs.  

We are working on the structure and function of G protein-coupled receptor implicated in mental diseases or cancer and perceiving smell and taste. We employ multiple approaches, including structural biology, biophysics, molecular pharmacology, and computational chemistry, to elucidate the molecular mechanism of the cell signaling mediated by G protein-coupled receptors. We will leverage the molecular mechanism to develop novel or better therapeutics that modulate these signaling pathways.

^{* Contribute equally  # Co-correspondence}

^{1. Jie Yin*, Yanyong Kang*, Aaron McGrath*, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach#, Jef K. De Brabander#, Daniel M. Rosenbaum#.  Molecular mechanism of the wake-promoting agent TAK-925. Nature Communications (2022, accepted)}

^{2. Jan Hellmann*, Matthäus Drabek*, Jie Yin*, Jakub Gunera, Theresa Pröll, Frank Kraus, Christopher J. Langmead, Harald Hübner,  Dorothee Weikert,  Peter Kolb#,  Daniel M. Rosenbaum#, and  Peter Gmeiner#. Structure-based development of a subtype-selective orexin 1 receptor antagonist. Proc. Natl. Acad. Sci. 117 (30), 18059-18067 (2020).}

^{3. Jie Yin, Kuang-Yui M. Chen, Mary J. Clark, Mahdi Hijazi, Punita Kumari, Xiao-chen Bai, Roger K. Sunahara#, Patrick Barth# & Daniel M. Rosenbaum#.  Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane. Nature 584, 125-129 (2020).}

4. Zhenhua Shao, Wei Yan, Karen Chapman, karthik Ramesh, Aaro J. Ferrell, Jie Yin, Xuehui Wang, Qingping Xu and Daniel M. Rosenbaum. Structure of an allosteric modulator bound to the CB1 cannabinoid receptor. Nat. Chem. Biol. 15, 1199–1205 (2019).

5. Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkönig, Baptiste Fischer, Daniel M. Rosenbaum, Brian K. Kobilka, Els Pardon & Jan Steyaert.  An improved yeast surface display platform for the screening of nanobody immune libraries. Scientific Reports 9(1): 382 (2019)

_{6. Jie Yin, Karen Chapman, Lindsay D. Clark, Zhenhua Shao, Dominika Borek, Qingping Xu, Junmei Wang and Daniel M. Rosenbaum. Crystal structure of the human NK1 tackykinin receptor. Proc. Natl. Acad. Sci. 115(52), 13264-13269 (2018).}

7. Jie Yin and Daniel M. Rosenbaum.  The Human Orexin/Hypocretin Receptor Crystal Structures. Curr. Topics. Behav. Neurosci. Doi: 10.1007/7854_2016_52

_{8. Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang and Daniel M. Rosenbaum.  High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature 540, 602-606 (2016).}

_{9. Yin, J., Babaoglu, K., Brautigam, C.A., Clark, L., Shao, Z., Scheuermann, T.H., Harrell, C.M., Gotter, A.L., Roecker, A.J., Winrow, C.J., Renger, J.J., Coleman, P.J. and Rosenbaum, D.M. Structures and ligand-binding mechanism of the OX1 and OX2 orexin receptor. Nat. Struct. Mol. Biol. 23, 293-299 (2016).}

_{10. Jie Yin, Juan Carlos Mobarec, Peter Kolb, and Daniel M. Rosenbaum. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Nature 519, 247-250 (2015).}