Tongfei A. Wang
2005-2012 Ph.D. in Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign
2001-2005 B.S. in Biological Science, Peking University
2020-present Assistant Investigator, Chinese Institute of Brain Research, Beijing
2012-2020 Postdoctoral Scholar, University of California, San Francisco
The Wang Lab is interested in the homeostatic regulation of metabolism-related physiology and behavior. Our current research focuses on dissecting the neural circuitry of the anterior hypothalamus in rodents, with two major research focuses: 1) control of body temperature mediated by the preoptic area, and 2) the circadian clock mediated by the suprachiasmatic nucleus. Our long-term goal is to establish a mechanistic understanding of mammalian hibernation and its potential application in clinic.
Research in the Wang Lab is oriented around scientific questions, but not specific techniques. Modern neuroscience research benefits from the integration of multidisciplinary approaches; we thus employ a diverse set of experimental strategies in our research programs, including but not limited to electrophysiology, real-time imaging, optogenetics, neuronal tracing, single-cell RNA-seq, mass-spec, and animal behavior analysis. We are also actively involved in developing novel technologies for neuroscience research.
1. Wang, T.A., Teo, C.F., Akerblom, M., Chen, C., Diaz, A., McManus, M.T., Jan, Y.N., Jan, L.Y. (2019) Thermoregulation via Temperature-dependent PGD2 Production in Mouse Preoptic Area. Neuron. 103: 309–322. PMID: 31151773. (Featured by previews in Neuron and Nat Rev Neurosci)
2. Huang, X., He, Y., Dubuc, A.M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T.A., Stehbens, S.J., Younger, S., Barshow, S., Zhu, S., Cooper, M.K., Peacock, J., Ramaswamy, V., Garzia, L., Wu, X., Remke, M., Forester, C.M., Kim, C.C., Weiss, W.A., James, C.D., Shuman, M.A., Bader, G.D., Mueller, S., Taylor, M.D., Jan, Y.N., Jan, L.Y. (2015) EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 18(9):1236-46. PMID: 26258683.
3. Feenstra, B., Pasternak, B., Geller, F., Carstensen, L., Wang, T., Huang, F., Eitson, J.L., Hollegaard, M.V., Svanström, H., Vestergaard, M., Hougaard, D.M., Schoggins, J.W., Jan, L.Y., Melbye, M., Hviid, A. (2014) Common variants associated with general and MMR vaccine–related febrile seizures. Nat Genet. 46(12):1274-82. PMID:25344690. (Featured by previews in Nat Genet)
4. Rajashekar, I., Wang, T.A., Gillette, M.U. (2014) Circadian gating of neuronal functionality: a basis for iterative metaplasticity. Frontiers in Systems Neuroscience. 8: 164. PMID: 25285070.
5. Gillette, M.U., Wang, T.A.. (2014). Brain Circadian Oscillators and Redox Regulation in Mammals. Antioxidants & Redox Signaling (Invited Forum Review). 20(18):2955-65. PMID: 24111727.
6. Govindaiah, G., Wang, T., Gillette M.U., Cox, C.L. (2012). Activity-dependent regulation of retinogeniculate signaling by metabotropic glutamate receptors. J Neurosci. 32(37):12820-31. PMID: 22973005.
7. Wang, T.A., Yu, Y.V., Govindaiah, G., Ye, X., Artinian, L., Coleman, T., Sweedler, J.V., Cox, C.L., Gillette, M.U. (2012). Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons. Science. 337 (6096): 839-842. PMID: 22859819. (Featured by previews in Science and Sci Signal)
8. Govindaiah, G., Wang, T., Gillette, M.U., Crandall, S.R., Cox C.L. (2010). Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus. J Neurophysiol. 104(5): 2757-2765. PMID: 20884758.
9. Wang, T., Zhou, C., Tang, A., Wang, S., Chai, Z. (2006). Cellular Mechanism for Spontaneous Calcium Oscillations in Astrocytes. Acta Pharmacologica Sinica. 27 (7): 861–868. PMID: 16787570.
