Yang Xiang

Associate Investigator

Ph.D.

yang.xiang@cibr.ac.cn

Education Experience

Professional Experience

Research Description

Publications

Superscripts ^p, ^g, ^u, and ^ra denote postdoctoral fellows, graduate students, undergraduate students, and research assistants from our laboratory, respectively. Asterisks (*) indicate corresponding author(s).

1. Gong J^p, Nirala N, Chen J, Wang F^g, Gu P^p, Wen Q, Ip YT*, Xiang Y* (2023) TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila. Science Advances http://doi.org/10.1126/sciadv.adc9660.

2. Wang F^g, Ruppell KT^g, Zhou S, Qu Y, Gong J^p, Shang Y^g, Wu J, Liu X, Diao W, Li Y*, Xiang Y* (2023) Gliotransmission and adenosine signaling promote axon regeneration. Developmental Cell. https://doi.org/10.1016/j.devcel.2023.03.007. News report: https://www.umassmed.edu/news/news-archives/2023/09/study-shows-neuron-glia-crosstalk-important-factor-in-axon-regeneration/

3. Gong J^p, Chen J, Gu P^p, Shang Y^g, Ruppell KT^g, Yang Y^ra, Wang F^g, Wen Q*, Xiang Y* (2022) Shear stress activates nociceptors to drive Drosophila mechanical nociception. Neuron. doi: 10.1016/j.neuron.2022.08.015. PMID: 36087585. News report:

https://medicalxpress.com/news/2022-12-hints-potentially-crucial-role-stress.html

4. Gu P^p, Wang F^g, Shang Y^g, Liu J, Gong J^p, Xie W, Han J, Xiang Y* (2022) Nociception and hypersensitivity involve distinct neurons and molecular transducers in Drosophila. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2113645119. PMID: 35294287.

5. Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT^g, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE (2020) TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca²⁺. Nat Commun. doi: 10.1038/s41467-020-16411-5. PMID: 32471994.

6. Gu P^p, Gong J^p, Shang Y^g, Wang F^g, Ruppell KT^g, Ma Z, Sheehan AE, Freeman MR, Xiang Y* (2019) Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Curr Biol. doi: 10.1016/j.cub.2019.09.070. PMID: 31735672.

7. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F^g, Li T, Thompson-Peer KL, Gong J^p, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN (2019) The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. DOI: 10.1016/j.neuron.2019.01.050. PMID: 30819546.

8. Yan C, Wang F^g, Peng Y, Williams CR, Jenkins B, Wildonger J, Kim HJ, Perr JB, Vaughan JC, Kern ME, Falvo MR, O'Brien ET 3rd, Superfine R, Tuthill JC, Xiang Y, Rogers SL, Parrish JZ (2018) Microtubule Acetylation Is Required for Mechanosensation in Drosophila. Cell Rep. DOI: 10.1016/j.celrep.2018.09.075. PMID: 30355484.

9. Guntur AR, Gou B, Gu P^p, He R, Stern U, Xiang Y, Yang CH (2017) H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. Genetics. doi: 10.1534/genetics.116.195172. PMID: 27932542.

10. Wu X, Zhang Y, Ruppell KT^g, Bilsel O, Li Z, Lee H, Zhang Z, Li D, Fan W, Duan C, Chan EM, Lois C, Xiang Y, Han G (2016) Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano. doi: 10.1021/acsnano.5b06383. PMID: 26736013.

11. Im SH, Takle K^g, Jo J, Babcock DT, Ma Z, Xiang Y, Galko MJ (2015) Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. Elife. 2015 doi: 10.7554/eLife.10735. PMID: 26575288.

12. Guntur AR, Gu P^p, Takle K^g, Chen J^u, Xiang Y*, Yang CH* (2015) Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1514862112. PMID: 26443856.

13. Yang L, Li R, Kaneko T, Takle K^g, Morikawa RK, Essex L, Wang X, Zhou J, Emoto K, Xiang Y, Ye B (2014) Trim9 regulates activity-dependent fine-scale topography in Drosophila. Curr Biol. doi: 10.1016/j.cub.2014.03.041. PMID: 24746793.

14. Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L., Meltzer, S., Jan, L.Y., & Jan, Y.N. (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493: 221-225. PMC3917554

15. Yuan, Q., Xiang, Y., Yan, Z.Q., Han, C., Jan, L.Y., & Jan, Y.N. (2011). Light induced structural and functional plasticity in Drosophila larval visual System. Science 333: 1458-1462. PMC4114502

16. Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y. and Jan, Y. N. (2010). Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468: 921-926. PMC3026603 (Research Article). News and Views article in Nature: 468: 900-901

17. Yang, C., Rumpf, S., Xiang, Y., Gordon, M. D., Song, W., Scott, K., Jan, L. Y. and Jan, Y. N. (2009). Control of post-mating behavior switch in Drosophila females by internal sensory neurons. Neuron 61:519-526. PMC2748846

18. Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X., Wu, C., Poo, M. and Duan, S. (2002) Nerve growth cone guidance mediated by G protein-coupled receptors. Nature Neuroscience 5:843-848.