Lei Zhang

Advances in brain science are closely driven by innovations in technology and instrumentation. The Instrumentation Core conducts research and development of advanced instruments and devices tailored to the cutting-edge needs of neuroscience. It also supports translational research and development of clinical technologies and medical devices for the diagnosis and treatment of brain disorders. In addition, the Core is responsible for the system integration of the implantable brain-machine interfaces (BMIs) developed at the Institute.

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*First author, # Corresponding author

1. Shi, W.*, Huang, H.*, Sun, X., Jia, Q., Zhou, Y., Zhu, M., Tian, M., Li, Z., Zhang, Z., Wang, T. A., Zhang, L.#, A Miniaturized Implantable Telemetry Biosensor for the Long-Term Dual-Modality Monitoring of Core Temperature and Locomotor Activity. Bioengineering, 12(6), 673. (2025)

2. Di R., Du Q., Xie Y., Lu Y., Gao W., Zhang, L., Qi X., Fan Y., Li J., Wang F., Chen S., Chen T. #, A mechano-resistance mechanism in skin adapts to terrestrial locomotion, Cell, 188 (21): 5797-5808. (2025)

3. Pang, R.*, Sang, H.*, Yi, L., Gao, C., Xu, H., Wei, Y. #, Zhang, L. #, Sun, J. #, Working memory load recognition with deep learning time series classification. Biomedical optics express, 15(5), 2780–2797. (2024)

4. Du, Y., Qi, X., Zhang, L. Yang Y., Chen T. #, Calcium influx-induced lytic cell death disrupts skin immune homeostasis. Cell Discov 9, 124 (2023).

5. Lin, S.*, Wang, D.*, Sang, H.*, Xiao, H., Yan, K., Wang, D., Zhang, Y., Yi, L., Shao, G., Shao, Z., Yang, A.#, Zhang, L.#, Sun, J.#, Predicting poststroke dyskinesia with resting-state functional connectivity in the motor network. Neurophotonics, 10(2), 025001. (2023)

6. Qu, S., Zhu, Q., Zhou, H., Gao, Y., Wei, Y., Ma, Y., Wang, Z., Sun, X., Zhang, L., Yang, Q., Kong, L., & Zhang, L., EasyFlyTracker: A Simple Video Tracking Python Package for Analyzing Adult Drosophila Locomotor and Sleep Activity to Facilitate Revealing the Effect of Psychiatric Drugs. Frontiers in behavioral neuroscience, 15, 809665. (2022)

7. Zhang L.*, Chen K.*, Wang S., Chen S., Niu S., Wang Z. #, Du P., Synthesis of percolative hyperelastic conducting composite and demonstrations of application in wearable strain sensors. Mater. Lett., 233: 306-309.（2018）

8. Li Y.*, Zhang L.*, Long K., Gong H. #, Lei H. #, 2018. Real-time monitoring prefrontal activities during online video game playing by functional near-infrared spectroscopy. J. Biophotonics, 11(9):e201700308.（2018）

9. 张垒、邓勇、骆清铭，近红外光谱分析技术实用手册，第10章：近红外光谱在脑功能研究中的应用，机械工业出版社出版. (2016)

10. Gao C., Zhang L., Luo D., Liu D., Gong H. #, PFC Activity Pattern During Verbal WM Task in Healthy Male and Female Subjects: A NIRS Study. Advances in Experimental Medicine and Biology, 923.（2016）

11. Zhang L., Sun J., Sun B., Luo Q., Gong H. #,. Studying hemispheric lateralization during a stroop task through near-infrared spectroscopy-based connectivity. J. Biomed. Opt., 19(5):057012.（2014）

12. Sun B., Zhang L., Gong H., Sun J., Luo Q. #, Detection of optical neuronal signals in the visual cortex using continuous wave near-infrared spectroscopy. Neuroimage, 87: 190-198.（2014）

13. Zhang L., Sun J., Sun B., Luo Q., Gong H. #, Studying hemispheric lateralization during a Stroop task by near-infrared spectroscopy. Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892814.（2014）

14. Zhang L.*, Sun J.*, Sun B., Gao C., Gong H. #, Detecting bilateral functional connectivity in the prefrontal cortex during a stroop task by near-infrared spectroscopy. J. Innov. Opt. Health Sci. 6, 1350031.（2013）

15. Sun J., Sun B., Zhang L., Luo Q., Gong H. #, Correlation between hemodynamic and electrophysiological signals dissociates the neural correlates of conflict detection and resolution in a stroop task: a simultaneous near-infrared spectroscopy and event-related potential study. J. Biomed. Opt., 18(9):096014.（2013）

16. Zhang Z.*, Sun B.*, Gong H., Zhang L., Sun J., Wang B., Luo Q. #, A fast neuronal signal-sensitive continuous-wave near-infrared imaging system. Rev. Sci. Instrum., 83, 094301.（2012）

17. Wang B., Xu G., Tian Q., Sun J., Sun B., Zhang L., Luo Q. #, Gong H., Difference between the vastus lateralis and gastrocnemius lateralis in the assessment ability of breakpoints of muscle oxygenation for aerobic capacity indices during an incremental cycling exercise. J. Sport. Sci. Med., 11, 606-613.（2012）

11 granted invention patents and 14 utility model patents; participation in drafting one industry standard for Brain-Machine Interface medical devices.