Wei Shi
2011 – 2017 Ph.D. in Neuroscience, Weill Cornell Medicine & Sloan Kettering Institute, New York, NY, USA
2007 – 2011 B.S. in Biology, Sichuan University, Sichuan, P. R. China
2025-present Assistant Investigator, Chinese Institute for Brain Research, CIBR, Beijing, China
2021 – 2025 Independent Research Fellow, Chinese Institute for Brain Research, CIBR, Beijing, China
2017 – 2020 Research Scholar, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
We are interested in exploring the bi-directional communication between the nervous system and peripheral tumor. Our primary focus is to understand how peripheral changes caused by tumors disrupt neural circuits in the brain. Reciprocally, we investigate how manipulation of the sympathetic nervous system, which carries the majority of efferent signals from the brain to the body, influences peripheral tumor growth. The goal is to exploit vulnerabilities in neural signaling to develop more effective cancer therapies.
1. Shi Y.*, Sun Q.*, Jia F., Xie X., Zhou X., Guo R., Zeng Y., Chen S., Guo Z., Sun W., Guo T., Xia Y., Li W., Zhang L., Shi W.CA & Yu Y.CA (2025) Oncogenic fusions converge on shared mechanisms in initiating astroblastoma. Nature. 643, 551–561. (* Co-first author)
2. Do M.H.*, Shi W. *, Ji L. *, Ladewig E., Zhang X, Srivastava R.M., Capistrano K.J., Edwards C., Malik I., Nixon B.G., Stamatiades E.G., Liu M., Li S., Li P., Chou C., Xu Ke., Hsu T, Wang X, Chan T.A., Leslie C.S., Li MO. (2023) Reprogramming tumor-associated macrophages to outcompete endovascular endothelial progenitor cells and suppress tumor neoangiogenesis. Immunity 56(11): 2555-2569. (* Co-first author)
3. Zhang X, Li S, Malik I, Do MH, Ji L, Chou C, Shi W, Capistrano KJ, Zhang J, Hsu TW, Nixon BG, Xu K, Wang X, Ballabio A, Schmidt LS, Linehan WM, Li MO. (2023) Reprogramming tumour-associated macrophages to outcompete cancer cells. Nature 619(7970):616-623.
4. Liu M., Kuo F., Capistrano K.J., Kang D., Nixon B.G., Shi W., Chou C., Do M.H., Stamatiades E.G., Gao S., Li S., Chen Y., Hsieh J.J., Hakimi A.A., Taniuchi I., Chan T.A., Li MO. (2020) TGF-β Suppresses Type 2 Immunity to Cancer. Nature 587(7832):115-120. (PMID: 33087928)
5. Li S., Liu M., Do M.H., Chou C., Stamatiades E.G., Nixon B.G., Shi W., Zhang X., Li P., Gao S., Capistrano K.J., Xu H., Cheung N-K. V., Li MO. (2020) Cancer Environment Immunotherapy via Targeted TGF-β Signaling Blockade in Helper T Cells. Nature 587(7832):121-125. (PMID: 33087933)
6. Shi W., Xinyu A., Han Z., Tang X., Li Z., Zhong H., Mao T., Huang K., and Shi S.-H. (2017) Ontogenetic Establishment and Order-specific Nuclear Organization in the Mammalian Thalamus. Nat. Neurosci. 20(4):516-528. (PMCID: PMC5374008)
7. Legue E., Gottshall J.L., Jaumouille E., Rosello-Diez A., Shi W., Barraza L.H., Washington S., Grant R.L., Joyner A.L. (2016) Differential Timing of Granule Cell Production during Cerebellum Development Underlies Generation of the Foliation Pattern. Neural Dev. 11: 17. (PMCID: PMC5017010)
8. Tan X., Liu W.A., Zhang X., Shi W., Ren S., Li Z., Brown K.N., Shi S.-H. (2015) Vascular Regulation of Neocortical Interneuron Production. Dev. Cell 36: 624-638. (PMID: 27003936)
9. Xu H., Han Z., Gao P., He S., Li Z., Shi W., Kodish O., Shao W., Brown K.N., Huang K., Shi S.-H. (2014) Distinct Lineage-Dependent Structural and Functional Organization of the Hippocampus. Cell 157: 1552–1564. (PMCID: PMC4120073)
10. Sultan K.T.*, Shi W.*, Shi S.-H. (2014) Clonal Origins of Neocortical Interneurons. Curr. Opin. Neurobiol. 26:125–131. (Review article, * Co-first author) (PMCID: PMC4024342)
