Zilong Gao

CIBR is committed to integrating basic research, clinical research, and applied research to achieve the "bench to bedside" of new mechanisms, new targets, and new technologies. Behavioral phenotyping is vital for studying neural circuit mechanisms, neural diseases modeling, preclinical pharmaceutical evaluation, etc. In addition to state-of-the-art equipment, we will provide facilities and expertise in experimental design, data analysis, and interpretation by implementing advanced behavior paradigms, machine learning, brain-machine interface technology, and so on. We will ultimately build up a scaled, automized, standardized behavioral phenotyping facility at CIBR.

Furthermore, We actively collaborate with research groups involved in brain science research at CIBR and other teams in Beijing and the surrounding areas. Over time, we will establish behavioral databases for various neurological diseases, facilitating high-throughput and standardized solutions for neurological disease detection, behavioral phenotyping analysis, and drug screening.

1. Cao S^#, Wu Y^#, Gao Z^#, Tang J, Xiong L, Hu J, Li C. Automated phenotyping of postoperative delirium-like behavior reveals the therapeutic efficacy of dexmedetomidine. Communications Biology (Inpress, ^#Co-first author)
2. Pan Q^#, Guo S^#, Chen M, Su X, Gao Z, Wang Q, Xu T, Liu M, Hu J. Representation and control of pain and itch by distinct prefrontal neural ensembles. Neuron 2023. Epub 2023/05/23. doi: 10.1016/j.neuron.2023.04.032
3. Lu C^#, Zhu X^#, Feng Y^#, Ao W, Li J, Gao Z, Luo H, Chen M, Cai F, Zhan S, Li H, Sun W, Hu J. Atypical antipsychotics antagonize GABA(A) receptors in the ventral tegmental area GABA neurons to relieve psychotic behaviors. Molecular Psychiatry. 2023. Epub 2023/02/09. doi: 10.1038/s41380-023-01982-8
4. Lu C^#, Feng Y, Li H, Gao Z, Zhu X, Hu J. A preclinical study of deep brain stimulation in the ventral tegmental area for alleviating positive psychotic-like behaviors in mice. Frontiers in Human Neuroscience. 2022;16:945912. Epub 2022/08/30. doi: 10.3389/fnhum.2022.945912.
5. Zeng Y^#, Luo H^#, Gao Z, Zhu X, Shen Y, Li Y, Hu J, Yang J. Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine. iScience. 2021;24(3):102213. doi: 10.1016/j.isci.2021.102213.
6. Guo J^#, Ran M^#, Gao Z, Zhang X, Wang D, Li H, Zhao S, Sun W, Dong H, Hu J. Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia. eBioMedicine. 2021;65:103272. doi: 10.1016/j.ebiom.2021.103272.
7. Gao Z^#, Wang H^#, Lu C, Lu T, Froudist-Walsh S, Chen M, Wang XJ, Hu J, Sun W. The neural basis of delayed gratification. Science Advances. 2021;7(49):eabg6611. doi: 10.1126/sciadv.abg6611. (^#Co-first author)
8. Li J^#, Lu C^#, Gao Z, Feng Y, Luo H, Lu T, Sun X, Hu J, Luo Y. SNRIs achieve faster antidepressant effects than SSRIs by elevating the concentrations of dopamine in the forebrain. Neuropharmacology. 2020;177:108237. doi: 10.1016/j.neuropharm.2020.108237.
9. Wang F^#, Zhang J, Yuan Y, Chen M, Gao Z, Zhan SL, Fan C, Sun W, Hu J. Salience processing by glutamatergic neurons in the ventral pallidum. Science Bulletin. 2020;65(5):389-401. doi: 10.1016/j.scib.2019.11.029.
10. Gao Z^#, Wu R^#, Chen C^#, Wen B^#, Liu Y, Lu W, Chen N, Feng J, Fan R, Wang D, Cui S, Wang JH. Coactivations of barrel and piriform cortices induce their mutual synapse innervations and recruit associative memory cells. Brain Research. 2019:146333. doi: 10.1016/j.brainres.2019.146333. (^#Co-first author)
11. Yan F^#, Gao Z^#, Chen P^#, Huang L^#, Wang D, Chen N, Wu R, Feng J, Cui S, Lu W, Wang JH. Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plasticity. 2016;2016:5648390. doi: 10.1155/2016/5648390. (^#Co-first author)
12. Gao Z^#, Chen L^#, Fan R^#, Lu W, Wang D, Cui S, Huang L, Zhao S, Guan S, Zhu Y, Wang JH. Associations of Unilateral Whisker and Olfactory Signals Induce Synapse Formation and Memory Cell Recruitment in Bilateral Barrel Cortices: Cellular Mechanism for Unilateral Training Toward Bilateral Memory. Frontiers in Cellular Neuroscience. 2016;10:285. doi: 10.3389/fncel.2016.00285. (^#Co-first author)
13. Wang D^#, Zhao J^#, Gao Z^#, Chen N, Wen B, Lu W, Lei Z, Chen C, Liu Y, Feng J, Wang JH. Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals. Frontiers in Cellular Neuroscience. 2015;9:320. doi: 10.3389/fncel.2015.00320. (^#Co-first author)
14. Zhang G^#, Gao Z^#, Guan S, Zhu Y, Wang JH. Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs. Molecular Brain. 2013;6:2. doi: 10.1186/1756-6606-6-2. (^#Co-first author)
15. Ye B^#, Huang L^#, Gao Z, Chen P, Ni H, Guan S, Zhu Y, Wang JH. The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. PloS one. 2012;7(8):e41986. doi: 10.1371/journal.pone.0041986.