Lei Gao
2012-2016 B.S. Harbin Institute of Technology
2016-2022 Ph.D. University of Chinese Academy of Sciences / National Center for Nanoscience and Technology
2022-present Research Fellow, Chinese Institute for Brain Research (CIBR), Beijing, China
Compared to rigid probes, flexible neural probes have been developed to reduce the mechanical mismatch between probes and brain tissues, leading to greatly reduced chronic inflammatory responses. Our lab focuses on developing high-density flexible neural probes with smaller implantation injuries and better long-term recording capabilities by combining new-type electrode structure (using microfabrication), material and implantation method. The prepared flexible neural probes are applied to stably record long-term in vivo neural activities.
1. Gao L*CA, Lv S*, Shang Y, Guan S, Tian H, Fang Y, Wang JCA, Li HCA. (2024) Free-standing carbon nanotube embroidered graphene film electrode array for stable neural interfacing. Nano Letters, 24(3): 829-835.
2. Yang S, Xu K, Guan S, Zou L, Gao L, Wang J, Tian H, Li H, Fang Y, Li HCA. (2023) Polymer nanofiber network reinforced gold electrode array for neural activity recording. Biomedical Engineering Letters, 13(2): 111-118.
3. Gao L*, Wang J*, Zhao Y*, Li H, Liu M, Ding J, Tian H, Guan S, Fang YCA. (2022) Free-standing nanofilm electrode arrays for long-term stable neural interfacings. Advanced Materials, 34(5), 2107343.
4. Zou L*, Tian H*, Guan S, Ding J, Gao L, Wang J, Fang YCA. (2021) Self-assembled multifunctional neural probes for precise integration of optogenetics and electrophysiology. Nature Communications, 12(1): 1-9.
5. Zou Y*, Wang J*CA, Guan S, Zou L, Gao L, Li H, Fang Y, Wang CCA. (2021) Anti-fouling peptide functionalization of ultraflexible neural probes for long-term neural activity recordings in the brain. Biosensors and Bioelectronics, 192, 113477.
6. Gao L* Wang J*, Guan S, Du M, Wu K, Xu K, Zou L, Tian H, Fang YCA. (2019) Magnetic actuation of flexible microelectrode arrays for neural activity recordings. Nano Letters, 19(11): 8032-8039.
7. Du M*, Guan S*, Gao L, Lv S, Yang S, Shi J, Wang J, Li HCA, Fang YCA. (2019) Flexible micropillar electrode arrays for in vivo neural activity recordings. Small, 15(20): 1900582.
8. Guan S*, Wang J*, Gu X*, Zhao Y, Hou R, Fan H, Zou L, Gao L, Du M, Li CCA, Fang YCA. (2019) Elastocapillary self-assembled neurotassels for stable neural activity recordings. Science Advances, 5(3): eaav2842.
