Technician Opportunity: Join the Chen Lab at CIBR!

Technician Positions Available in the Chen Lab at CIBR

About Chen Lab

Chen Lab is dedicated to research related to brain tumors, elucidating the mechanisms of brain tumor development, the regulatory network of the immune microenvironment, and the molecular basis of drug resistance.

Direction 1: Discovering novel endogenous targets and pathways in tumors. Utilizing patient-derived primary cells and innovative mouse models, combined with CRISPR functional genomics and high-throughput screening technologies, the laboratory systematically discovers and validates key targets and signaling pathways driving the malignant progression of gliomas.

Direction 2: Analyzing the tumor immune microenvironment. Employing single-cell genomics and mouse genetic models, the laboratory delves into the unique tumor immune microenvironment (TME) of the brain, aiming to identify key cellular subsets and regulatory networks mediating immune escape, paving the way for the development of next-generation immunotherapies.

We translate basic scientific discoveries into innovative therapeutic approaches, actively developing small molecule drugs, biological macromolecules (antibodies), oncolytic viruses, and CAR-T cell therapies. Many of the laboratory's groundbreaking findings have been published in top international journals such as Nature, Cell, Nature Cell Biology, Genes & Development, and Cancer Cell. It has successfully driven several investigator-initiated clinical trials (IITs). Lab Webpage： https://chenlab.cibr.ac.cn

Job Opening: Laboratory Animal Administrator, Drug Screening Technician

Position 1：Laboratory Animal Administrator

Job Responsibilities:

1. Responsible for the daily management of laboratory mice, including daily feeding, cage inspection, co-breeding, weaning and separation, strain preservation, pedigree recording, and health monitoring;

2. Participate in basic animal experiments, including mouse perfusion, sectioning, staining, and stereotactic injection;

3. Strictly adhere to laboratory animal ethics requirements, biosafety requirements, and all laboratory management regulations;

4. Assist the research group with animal surgeries, sample pretreatment, and other related research support work.

Job Requirements:

1. Bachelor's degree or above in Biology, Veterinary Medicine, Laboratory Animal Science, or related fields;

2. Highly responsible, motivated, hardworking, and meticulous;

3. Meticulous, responsible, adaptable to the working environment of a barrier animal facility, and no allergy to animal fur;

4. Good communication skills, a team player, and willing to work long-term.

Position 2: Drug Screening Technician

Job Responsibilities:

1. In vitro drug screening and mechanism research:

- Model development and optimization: Responsible for developing and optimizing drug screening models based on cellular and molecular levels, including but not limited to cell viability testing, reporter gene systems, and enzyme activity assays;

- High-throughput screening execution: Operate automated liquid handling systems and high-throughput screening equipment to perform routine and medium-throughput compound activity screening, and complete dose-response evaluation and preliminary structure-activity relationship analysis;

- In-depth mechanism exploration: Conduct in-depth studies such as target binding verification, signal pathway detection, and protein-protein interaction analysis to elucidate the mechanism of action of compounds;

- Platform operation and optimization: Responsible for the daily operation and basic maintenance of related equipment, continuously optimizing experimental protocols and screening models to ensure data reliability, reproducibility, and compliance with standards.

2. In vivo pharmacodynamic evaluation:

- Pharmacodynamic experiment implementation: Responsible for in vivo pharmacodynamic experiments in mice and other laboratory animals, including disease model establishment (e.g., tumor transplantation, pharmacological induction), dosing regimen execution (gavage, injection, etc.), and regular observation and physiological indicator monitoring;

- Phenotypic analysis support: Independently or assist in small animal imaging analysis (e.g., in vivo imaging) and other relevant phenotypic analyses.

3. Data management and research support:

- Experimental record keeping and compliance: Rigorous, standardized, and timely recording of experimental processes and raw data, ensuring all operations and research comply with ethical and compliance requirements;

- Data analysis and presentation: Perform statistical analysis and visualization of experimental data, and write structured experimental reports;

- Results reporting and collaboration: Regularly report research progress and results to the project leader, collaborate efficiently with the team, and support project decision-making and subsequent experimental design.

Job Requirements:

1. Bachelor's degree or above in biology, pharmacology, medicine, or a related field;

2. Solid molecular and cell biology experimental skills, proficient in cell culture, with preference given to candidates with backgrounds in medicinal chemistry synthesis, high-throughput drug screening, and pharmacological and pharmacodynamic research;

3. Priority given to candidates with experience in in vivo pharmacodynamic experiments, familiarity with basic animal handling (e.g., handling and fixation, administration via various routes, sample collection) and the construction and evaluation of animal disease models (e.g., tumor, autoimmune, metabolic models);

4. Proactive, responsible, with excellent hands-on skills, logical thinking ability, and meticulous research habits;

5. Good teamwork and communication skills, able to adapt to a fast-paced research environment;6. Willing to work in an animal facility, in good health, with no history of animal fur allergies or common drug allergies.

Benefits:

1. Competitive salary and benefits package based on the applicant's experience and abilities (negotiable on a case-by-case basis);

2. Formal employment contract, five social insurances and one housing fund, supplementary medical insurance, annual physical examination, paid annual leave, etc.;

3. Employee canteen, free shuttle bus, assistance in applying for employee dormitory, gym, etc.

4. First-class research facilities and ample research funding, opportunities to collaborate with top clinicians and scientists, a broad platform to support personal career development and promotion opportunities;

5. Full support for applying for national and provincial-level talent programs and research projects.

Application Materials :

Curriculum Vitae (CV)

Contact Information:

Please send your CV and relevant supporting documents in PDF format to chenjian@cibr.ac.cn, with the subject line "Name + Applied Position".